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| History |
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| Pharmacology |
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| Toxicology |
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| Adverse
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| Clinical
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SuperCool™
Palmetto is a standardized and enhanced Saw Palmetto product for
healthy prostate function and healthy hair follicles, attributes that
promote well-being in a significant amount of men over the age of
50 and increase with age [U.S. Patent Pending, 2003].
SuperCool™
Palmetto was developed by utilizing Aphios’ patented SuperFluids™
fractionation and manufacturing technologies. Saw palmetto as a dietary
supplement most commonly consists of a hexane or ethanolic and, more recently,
supercritical fluid extracts of the berries of the American Dwarf Palm
Tree (Serenoa repens) located in Florida.
Scientists at Aphios utilized the inhibition of testosterone metabolism
to dihydro-testosterone by 5-alpha reductase to identify bioactive fractions.
Inhibition of this enzyme, 5-alpha reductase, correlates positively with
prostate function and hair follicle health. As such, the inhibition of
this enzyme may result in healthy prostate function as well as healthy
hair follicles
Phytosterols (campesterol, stigmasterol, ß-sitosterol and stigmastanol)
content of these fractions were measured by gas chromatography. The highest
level of bioactivity, as measured by 5-alpha reductase inhibition, was
found in the bioactive fractions that had the highest phytosterol content.
Phytosterols are thus used as secondary standard for SuperCool™
Palmetto.
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